Metabolic health
5-Amino-1MQ
Approved registered clients only.
Data sheet
5-Amino-1MQ
This preview is the one-page Alpine Ascent sheet for 5-Amino-1MQ. It is the reference copy for reconstitution, frequency, and the figures printed on the sheet. Open it when you want the full page.
What it is
5-Amino-1MQ is studied for inhibiting nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular metabolism and energy regulation. NNMT is active in fat cells and has been linked to metabolic regulation and weight gain. By blocking this enzyme, 5-Amino-1MQ is researched for support of normal metabolic function, a fat-burning state, cellular NAD+ availability, and mitochondrial function and energy expenditure. Human research is still limited.
What researchers study it for
- Body recomposition and weight management
- Metabolic support and energy regulation
- Mitochondrial function and energy expenditure
- Mental clarity and cognitive support
- Healthy NAD+ levels
- Overall metabolic efficiency
How it may work
- Inhibits nicotinamide N-methyltransferase (NNMT)
- May promote a fat-burning metabolic state
- May support healthy NAD+ availability
- May enhance mitochondrial function and energy expenditure
- May support body recomposition and weight management
- May support mental clarity and cognitive function
Research timeline
1–2 weeks
Early changes in energy, focus, or metabolic function may be noted.
Weeks 3–4
Metabolic efficiency and energy levels may begin to improve.
Weeks 6–8
Gradual improvements in body composition and mental clarity may be observed.
90–120 days
Continued benefits may be assessed over a full cycle. Results are variable and human research is still limited.
50 mg research protocol
- Reconstitution
- 3 mL bacteriostatic water
- Final concentration
- 16.7 mg/mL
- Source dose
- 500 mcg once daily
- Frequency
- Daily
- Research duration
- 90–120 days
- Administration
- Subcutaneous injection in the morning, as noted on the sheet
- Syringe reference
- The unit marking is printed on the data sheet. Use that PDF as the reference copy.
Research duration on the sheet: 90–120 days on the source sheet.
Reconstitution
- 50 mg + 3 mL bacteriostatic water = 16.7 mg/mL.
Titration notes
- No dose-escalation schedule is provided on the source protocol.
- The suggested dose on the sheet is 500 mcg once daily for a 90–120 day cycle.
Important considerations
- For educational and research purposes only.
- Limited human-research data.
- Avoid use in active or recent cancer research subjects.
- Not recommended during pregnancy or breastfeeding.
- Store appropriately after reconstitution.
Evidence summary
- Human research
- Limited
- Animal research
- Significant
- Mechanistic evidence
- Strong
- Long-term safety data
- Limited
References
Completed published studies are listed below and labeled as in vitro, animal, or human research. Favorable and unfavorable results are both included, including cancer studies. This is not every paper on the compound, and it is not a recommendation or a dose.
Completed 5-Amino-1MQ reports are mouse studies. A completed human trial was not identified. A completed cancer study was not identified.
- NNMT inhibitors, including 5-amino-1MQ, reverse high-fat-diet obesity in miceAnimal
Diet-induced obese mice. Eleven days of 5-amino-1MQ limited further weight gain and reduced fat mass.
- NNMT inhibition with 5-amino-1MQ mitigates obesity-related metabolic dysfunctionAnimal
Obese mice treated for 28 days. Body composition, insulin-related measures, and fatty-liver findings improved compared with untreated obese mice.
Available strength
50 mg vial. Format: Lyophilized powder.
For educational and research purposes only. These materials are not approved to diagnose, treat, cure, or prevent any disease. Nothing on this page is a dose recommendation or medical advice. The Alpine Ascent data sheet is the reference copy for each compound.