Kisspeptin

Kisspeptin is a naturally occurring peptide that plays a central role in regulating the reproductive system. It acts as a key signaling molecule in the hypothalamus, where it stimulates the secretion of gonadotropin-releasing hormone (GnRH). GnRH then triggers secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary, both essential for puberty, fertility, and normal reproductive function.

• Stimulation of GnRH, LH, and FSH release
• Support for puberty and reproductive function
• Regulation of hormonal balance
• Potential role in fertility research
• Influence on reproductive health in both males and females
• Research into mood, metabolism, and related pathways

• Stimulates release of GnRH in the hypothalamus
• Triggers downstream secretion of LH and FSH
• Supports normal reproductive hormone function
• May influence timing of puberty and reproductive development
• Potential effects on mood and metabolic pathways are also discussed on the sheet

Reconstitution

1 mL bacteriostatic water

Final concentration

10 mg/mL (10,000 mcg/mL)

Starting dose

500 mcg (5 units)

Dosage range

500 mcg to 1,000 mcg (5–10 units)

Frequency

3 times per week

Cycle duration

4 weeks on, 4 weeks off

Administration

Subcutaneous injection, in a fasted state

Storage

Refrigerate after reconstitution

Research duration on the sheet: 4 weeks on and 4 weeks off on the source sheet.

• 10 mg + 1 mL bacteriostatic water = 10 mg/mL.
• 5 units = 500 mcg. 10 units = 1,000 mcg.

• The sheet lists a range of 500–1,000 mcg rather than a weekly escalation.
• Starting example: 500 mcg (5 units), 3 times per week.

• For research and educational purposes only.
• Not for human consumption.
• Use in a fasted state, as noted on the sheet.
• Conduct research in accordance with applicable laws and regulations.

Research status on the sheet

Investigational peptide, research use only

Completed published studies are listed below and labeled as in vitro, animal, or human research. Favorable and unfavorable results are both included, including cancer studies. This is not every paper on the compound, and it is not a recommendation or a dose.

Kisspeptin is the product of KISS1, first studied as a metastasis-suppressor gene. Some breast-cancer models later reported the opposite direction. The links below are the completed studies with a suppressor result.

• Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilizationHuman

  Women in IVF treatment. A single kisspeptin-54 injection matured eggs, and embryos from those eggs led to pregnancies.

• Intranasal kisspeptin rapidly stimulates gonadotropin release in humansHuman

  Healthy men and women, and women with hypothalamic amenorrhoea. Intranasal kisspeptin-54 raised luteinizing hormone compared with placebo.

• KiSS-1 peptide, metastin, and melanoma spreadIn vitro

  The KiSS-1 peptide blocked invasion in cultured cells and reduced lung metastases of melanoma cells in mice. It did not stop the first tumor from forming.

• KiSS-1 and metastasis of MDA-MB-435 cellsAnimal

  Mice. Cells carrying KiSS-1 still formed a tumor in the mammary fat pad, but metastatic spread fell by about 95% compared with control cells.

• Kiss-1 in colorectal cancer cells and tumor samplesIn vitro

  Removing Kiss-1 made colorectal cancer cells more invasive. Adding kisspeptin-10 reduced their migration. In patient samples, lower Kiss-1 tracked with more advanced stage.

• KiSS-1 as a melanoma metastasis-suppressor geneIn vitro

  Metastatic melanoma cells. Restoring the KiSS-1 gene suppressed their ability to spread. The experiment changed the gene inside the cells. It did not give the peptide.

• Kisspeptin, EIF2AK2, and cancer cell spreadAnimal

  Breast, prostate, and colorectal cancer cells moved and invaded less after kisspeptin. In mice, kisspeptin slowed colorectal tumor growth and reduced lung metastases. Blocking EIF2AK2 removed that effect.

10 mg vial. Format: Lyophilized powder.